Study on functionalization of biomaterials by controlling the high order structure

细胞膜上受体的大小和对黏附分子的识别是以纳米级调节的。因此，有必要对材料的三维结构进行设计和控制。因此，我们试图通过控制材料的纳米-微观-宏观结构来理解细胞在功能化生物材料上的真实识别机制。在本研究中，我们以(1)纤维二/三维阵列结构的控制和(2)浓聚聚合物刷的三维结构控制为目标，并对其身体机能特性进行了详细的检测。根据研究结果，提出了新型组织工程支架的概念。

The size of the receptor on the cellular membrane and the recognition of the adhesion molecules are regulated in nanometer order. Therefore it is necessary to design and to control the 3D structure of the materials. In this consequence, we try to understand the real cell recognition mechanism on the functionalized biomaterials by controlling the material nano-micro-macro structure. In this research, we aimed (1) "control of the second/three-dimensional array structure of the fiber" and (2) "three-dimensional structural control of the concentrated polymer brush", and the bodily function characteristic was examined in detail. From the results, the concept of the new type of the tissue engineering scaffolds was developed.