Identification and Functional Analysis of Cardiac Specific Singling Molecules and Therapeutic Applications for Cardiovascular Disease

在本研究项目中，我新发现了GS蛋白，其表达在心肌细胞中以不同的方式进行特异性调节。GS调节ATP合成的功能。我们还纯化并鉴定了一种新的AMPK底物CLIP-170，并阐明了AMPK在微管聚合中的调节作用。这两项发现为我们理解心肌细胞的应激反应和心血管疾病的治疗提供了新的思路。

In this research project, I newly discovered GS protein whose expression is regulated specifically different way in the cardiomyocyte. GS regulates the function of ATP synthesis. We also purified and identified a new AMPK substrate; CLIP-170 and clarified the regulatory role of AMPK in microtubule polymerization. Both discoveries lead to the understanding of novel cellular stress response in cardiomyocyte and the therapeutic approach of the cardiovascular diseases.