Development of a program aiming to recover cancer survivors' fitness

一些美国队列研究的结果表明，对于接受化疗的乳腺癌幸存者来说，体重增加会对他们的预后产生不利影响。在本研究中，我们使用体力活动监测器评估了接受乳腺癌化疗的日本受试者，平均88.7天。受试者的估计平均每日步数为6836.7步，平均体重增加3.3%。体重增加率与超过3.0 MET（代谢当量）的平均时间呈显著负相关。抑郁症的较高得分与平均时间少于1.5 MET密切相关。此外，化疗后的高体脂率与对身体健康状况的低感知（PCS;身体成分总结）相关。基于这些结果，我们认为，低体力活动导致体重增加和精神障碍。

Some USA cohorts' results of research indicated that for breast cancer survivors who received chemotherapy, weight gain was found to adversely affect their prognosis. In the present study, we evaluated Japanese subjects receiving chemotherapy for breast cancer using a physical activity monitor for an average 88.7 days. Estimated average daily steps in subjects were 6836.7 and average weight gain was 3.3%. The rate of weight gain was strongly negatively correlated with the average amount of time with more than 3.0 METs (metabolic equivalent). The higher score of depression was strongly correlated with the average amount of time with less than 1.5 METs. Moreover, high rate of total body fat after chemotherapy was correlated with low perception of physical health status (PCS; Physical Component Summary). Based on these results we suggest that low physical activity induced weight gain and mental disorder.