Activation of mesocorticolimbic dopaminergic system by environmental enrichment and trophic factor expression

为探讨中皮质边缘多巴胺能（DA能）系统在丰富环境（EE）发育大鼠中的功能，本研究通过对DA能受体、可卡因和苯丙胺相关转录本（CART）基因表达及情绪行为的分析，探讨DA能系统在EE发育中的作用。结果表明，EE改变了前额叶皮层和杏仁核中DA受体IV型和CART的表达，并且还发现在EE中生长的大鼠中情绪行为如焦虑行为减少。

To investigate the function of mesocorticolimbic dopaminergic (DAergic) system in developing rats grown in environmental enrichment (EE), gene expressions of DA receptors and cocaine- and amphetamine-related transcript(CART) and analysis of emotional behavior were carried out. It revealed that expression of DA receptor type IV and CART in prefrontal cortex and amygdala was altered by EE, and also found out that emotional behavior such as anxiety-behavior was reduced in rats grown in EE.