Skeletal muscle specific calpain p94 mediated signal transduction system

p94主要在骨骼肌中表达，是钙蛋白酶的一个成员，钙蛋白酶是需要Ca^<2+>的细胞内半胱氨酸蛋白酶。在这项研究中，我们发现p94蛋白酶活性的丧失会损害对物理应激的适应，并伴有运动依赖性的肌肉锚定重复蛋白-2和热休克蛋白上调的缺乏。此外，p94在肌细胞中根据肌小体条件改变其定位，介导外部应激的信号转导，其蛋白酶活性维持肌细胞稳态，其破坏导致肌肉萎缩。

p94 is predominantly expressed in skeletal muscle and is a member of calpains that are Ca^<2+>-requiring intracellular cysteine proteases. In this study, we revealed that loss of p94 proease activity impaired adaptation to physical stress, accompanied by deficiency in exercise-dependent up-regulation of muscle ankyrin-repeat protein-2 and heat-shock proteins. Furthermore, p94 changes its localization in myocytes depending on sarcomere conditions to mediate signal transduction in response to external stress, and its protease activity maintains myocyte homeostasis, disruption of which leads to muscular dystrophy.