Macaques as animal model for gamma-herpesvirus associated lymphomas

我们调查了γ -疱疹病毒（γ - hv）或sEBV的流行情况，并在日本猕猴（Macaca fuscata）和台湾猕猴(M。cyclopis)。我们发现，与这些猕猴物种中sEBV的高患病率相比，淋巴瘤的发病率非常低。在日本猕猴和台湾猕猴中发现了2例与sEBV相关的NK/ t细胞淋巴瘤。这些结果表明，这两个物种都适合用于γ - hv相关的人类淋巴瘤的动物模型。

We surveyed for the prevalence of gamma-herpes virus(γHV) or sEBV and 2) found out possible malignant cases caused by theγHVs infection retrospectively in Japanese macaques(Macaca fuscata) and Taiwanese macaques(M. cyclopis). We found that the incidence of the lymphoma was very low compared to the high prevalence of sEBV in those macaque species. Two cases suffering from NK/T-cell lymphoma associated with sEBV in Japanese macaques and Taiwanese macaques were detected. Those results suggest that both two species are suitable for an animal model for human lymphoma associated withγHV.