The Effects of Zolpidem and Triazolam, Rilmazafone Hydrochloride on The Physical and Cognitive Functions in Healthy, Elderly Persons

据报道，在老年人身上使用催眠药会出现许多问题，如平衡障碍、跌倒和记忆障碍。人们期望更安全的使用催眠药。我们研究了单剂量唑吡坦和三唑仑、盐酸利马沙丰对健康老年人身体和认知功能的影响。我们对14名健康老年人（平均年龄64.5岁）进行了双盲交叉试验，以研究单次给药唑吡坦（5mg）和三唑仑（0.125g）、盐酸利马沙酮（1mg）的残留效应。这些研究对象在晚上11点睡觉前服用安眠药或安慰剂。客观评估分别在催眠前的晚上10点和第二天的凌晨4点、6点、10点和下午2点进行。总摇摆通行证的结果是Rilmazafone明显优于安慰剂。利玛沙酮在CFF、TUG、记忆测试中的表现不如place、bo和唑吡坦。唑吡坦和三唑安定的FRT结果明显优于安慰剂。三唑仑对催眠后第二天受试者的认知功能和嗜睡无明显影响。众所周知，在评估老年人意外跌倒时，注重“动态平衡”的临床参数比注重“统计平衡”的临床参数更有用。本研究提示盐酸利马沙丰可能会增加摔倒的风险，因为这两种催眠药都会导致“动态平衡”的丧失。然而，利玛沙丰药物对主观感受的影响并不比安慰剂好。这些影响可能是由于盐酸利马沙丰的半衰期长。因此，受试者在第二天清晨就感到困倦。它可能对那些睡眠中断和早起的人有很好的影响。唑吡坦和三唑安定对健康老年人有良好的催眠作用，但对其第二天的客观和主观表现均无影响。少

Many problems have been reported on the use of hypnotics on the elderly, such as balance disorders, falling, and memory disorders. A safer use of hypnotics is being anticipated. We investigate the effects of a single dose of Zolpidem and Triazolam, Rilmazafone hydrochloride on the physical and cognitive function in healthy, elderly persons. We performed a double-blind crossover trial on 14 healthy elderly subjects (mean age 64.5 years) in order to investigate the residual effect of a single administration of Zolpidem (5mg) and Triazolam(0.125g), Rilmazafone hydrochloride(1mg). The subjects were given either hypnotics or a placebo at 11PM before going to bed. Objective assessments were conducted at 10PM before the subjects took the hypnotic, and at 4, 6, 10AM and 2PM the next day.The result of the Total Sway Pass was that Rilmazafone was significantly better than those of the placebo. However the results of Rilmazafone was not as good for the CFF and TUG, memory test than those of place … More bo and Zolpidem. The FRT results of Zolpidem and Triazolam were significantly better than those of the placebo. Triazolam showed little effect on the cognitive functions and the sleepiness of the subjects the day after hypnotic administration.It is known that clinical parameters which focus on the 'dynamic balance' are more useful than those which focus on 'statistic balance' in order to evaluate the accidental falls in the elderly. This study suggests that Rilmazafone hydrochloride may increase the risk of falling down because both hypnotics cause the lost of 'dynamic balance'.However, the feeling of Rilmazafone medication was not good for subjective feelings than that of a placebo. These effects may be due to Rilmazafone hydrochloride's long half- life. Therefore, subjects feel sleepiness early the next morning. It may have a good affect for the people who have interrupted sleep and early morning awakenings. Zolpidem and Triazolam have a hypnotic activity without disturbing objective and subjective performance on the following day when given to healthy elders. Less