Amelioration of tumor susceptibility by lifestyle modification in Snark-knockout mice

SNF1/AMPK相关激酶(SNF1/AMPK)缺陷小鼠表现出代谢紊乱。据报道，IL-6调节全身能量消耗，在这些小鼠中含量较低。自愿运动可恢复血清IL-6水平，改善代谢紊乱。Snark基因缺陷的小鼠也表现出致癌物质诱导的结直肠癌致瘤性增加。给予重组IL-6和自愿运动均可显著降低肿瘤易感性。这些结果表明，系统IL-6水平的恢复抑制了Snark基因缺陷小鼠的致瘤性，并提示了肿瘤发生和全身代谢紊乱的相伴关系。

SNARK (SNF1/AMPK-related kinase)-deficient mice exhibit metabolic disorders. IL-6, which has been reported to regulate whole body energy expenditure, was low in these mice. Voluntary exercise restored serum IL-6 level and ameliorated metabolic disorders. Snark-deficient mice also exhibited increased carcinogen-induced colorectal tumorigenesity. Both administration of recombinant IL-6 and voluntary exercise significantly reduced the tumor susceptibility. These findings imply that the restoration of systemic IL-6 level suppressed the tumorigenesity of Snark-deficient mice and the concomitance of tumorigenesis and systemic metabolic disorders were suggested.