Exploration for a Detox Pathway-Discovery and haracterization of New Genes in the Pathway

我们经常接触到来自食物和环境的有害物质。此外，我们的身体也产生这样的代谢物相当不友好我们自己的组织，细胞和遗传物质作为活性氧。然而，我们确实有天生的防御系统来抵御这些攻击。其中之一涉及解毒（排毒）酶系统，有害物质首先被识别，捕获，转化，最后排出体外。我们用模型动物C.他们发现XREP-1/XREP-3对在排毒系统中起着重要作用。XREP-1是识别有害物质的传感器，XREP-3是启动排毒酶生产的处理器。这一对类似于哺乳动物的Keap 1/Nfr 2对，表明类似的系统在人体中起作用。

We are constantly exposed to harmful substances from foods and environments. Besides, our body also produces such metabolites quite unkind to our own tissues, cells, and genetic materials as reactive oxygen species. We do have innate defense systems, however, against these assaults. One of them involves a detoxifying (detox) enzyme system, where harmful substances are first recognized, captured, transformed, and finally expelled outside the body. We explored this system using the model animal C. elegans and have found that an XREP-1/XREP-3 pair plays a vital role in the detox system. XREP-1 functions as a sensor to recognize harmful substances and XREP-3 as a processor to initiate the production of detox enzymes. This pair resembles the mammalian Keap1/Nfr2 pair, indicating that a similar system is working in the human body.