Mechanisms of functional differentiation in the Drosophila midgut

果蝇中肠具有吸收铜和分泌酸两种功能。这些功能是通过铜和间质细胞之间的细胞间通讯建立的。转录因子Dve有两种亚型（Dve-A、Dve-B），亚型转换的时空调节对于中肠的功能分化至关重要。此外，Rho GT3和V-ATPase的细胞类型特异性活性也是中肠功能所必需的。

The Drosophila middle midgut has two functions, copper absorption and acid secretion. These functions are established by intercellular communication between copper and interstitial cells. The transcription factor Dve has two isoforms (Dve-A, Dve-B), and the spatio-temporal regulation of isoform switching is cricial for functional differentiation of the midgut. In addition, the cell-type specific activities of Rho GTPase and V-ATPase are also required for the midgut functions.