Modulation of interferon action by intrinsic galectin-9 in cultured human endothelial cells.

利用Galectin-9的siRNA进行的基因敲除实验表明，内源性Galectin-9调节培养的人内皮细胞中的干扰素作用。然而，使用新一代siRNA进行的确认实验表明，观察到的结果是由于老一代siRNA的脱靶效应。过去一年的实验表明Galectin-9与人内皮细胞内质网应激(内质网应激)的关系。我正在继续研究Galectin-9在内皮细胞中与内质网应激有关的作用。

Knockdown experiments using siRNA of galectin-9 suggested that intrinsic galectin-9 modulates IFN action in cultured human endothelial cells. Confirmation experiments using new-generation siRNAs, however, demonstrated that the observation was due to the off-target effects of old-generation siRNAs. The experiments carried out on the last year suggested the relationship between galectin-9 and endoplasmic reticulum stress (ER stress) in human endothelial cells. I am continuing to investigate the role of galectin-9 in endothelial cells in relation to ER stress.