The Interactive Mechanisms of neural cell adhesion molecules ; Protocadherin and IgCAM.

免疫球蛋白超家族细胞黏附分子(IgCAM)和原钙粘附素家族成员(PcdH)在神经网络的形成中起着重要作用。这些成员蛋白不仅与各种细胞黏附蛋白，而且还与许多细胞外蛋白(ECM)具有血友性结合和异亲性结合的相互作用系统。IgCAMs和Pcdh尤其受硫酸软骨素蛋白多糖表达的调控。我们建立了参与合成硫酸软骨素的酶的基因敲除小鼠。在脑形成的发育阶段，IgCAMs和Pcdh的表达模式受到干扰。

Immunoglobulin superfamily cell adhesion molecules (IgCAM) and Proto-cadherin family members (Pcdh) play important roles in the neural network formations. These member proteins have the interaction systems of hemophilic binding and heterophilic bindings to not only various cell adhesion proteins but also many extra cellular proteins (ECMs). IgCAMs and Pcdh were regulated by the expression of chondroitin sulfate proteoglycans especially. We generated the knockout mice of the enzymes involved in the synthesizing of chondroitin sulfate. The expression pattern of IgCAMs and Pcdh were perturbed in the developmental stages of brain formation.