Developing the computing procedures and systems for genetic evaluation of resource animals using the chromosome segment model

本文研究了一种利用染色体片段模型进行资源动物遗传评价的计算程序和系统。使用大量SNP数据的遗传评估也考虑了几种方法。利用异种家畜小鼠和牛的模拟数据和实际数据，对这些计算方法的有效性进行了检验。理论和仿真研究表明，利用染色体片段模型对资源动物进行遗传评价是可行的。与使用多基因模型的混合模型方法相比，拟合SNP效应的贝叶斯方法在估计总遗传价值方面显得相对准确和有希望。

In this study, a computing procedure and system for genetic evaluation of resource animals using the chromosome segment model was considered. Those for the genetic evaluation using a large amount of SNP data were also investigated considering several approaches. Using simulated and actual data of hetero-stock mice and cattle, validities of those computing procedures were examined. Based on the theory and simulation study, the genetic evaluation of resource animals using the chromosome segment model was shown to be useful. Bayesian methods fitting SNP effects appeared to be relatively accurate and promising, in terms of estimation of total genetic merit, compared with the mixed model method using the polygene model.