Molecular basis of cerebrovascular disease with protein tyrosine phosphorylation in brain capillaries and therapeutic strategies

这项研究试图确定蛋白质酪氨酸磷酸化在中风后血脑屏障和随后的脑损伤的病理生理变化中的作用。本研究表明，紧密连接蛋白occludin酪氨酸磷酸化的增加与卒中后紧密连接的破坏和脑梗塞的发生有关，前列腺素EP1受体参与了occludin的酪氨酸磷酸化。此外，本研究提示，蛋白质酪氨酸磷酸化可能与卒中后NADPH氧化酶亚基水平的升高有关，NADPH氧化酶亚基被认为是一种活性氧物种的重要来源。

This study sought to determine the role of tyrosine phosphorylation of proteins in the pathophysiological alteration of the blood-brain barrier and subsequent brain injuries after stroke. This study demonstrates that the increase in the tyrosine phosphorylation of tight junctional protein occludin is linked to the disruption of tight junctions and the development of cerebral infarction after stroke and that the prostanoid EP1 receptor is involved in the tyrosine phosphorylation of occludin. In addition, this study suggests that protein tyrosine phosphorylation may be linked to the increase in the level of NADPH oxidase subunits, which are known as an important source of a reactive oxygen species, after stroke.