The myocardial metabolic function and its control molecules in cardiac hypertrophy

Takotsubo心肌病是一种越来越被认可的临床综合征，其特征是急性可逆性心尖室功能障碍。我们试图在非人类灵长类动物中建立一种新的takotsubo样心肌病模型。超声心动图显示，食食猴反复静脉注射过量肾上腺素引起takotsubo样心肌病，表现为左心室进行性和收缩功能下降，心尖区运动严重不足，基底区运动过度。尽管在没有任何治疗的情况下，这种心功能障碍在一个月后几乎恢复正常，但β受体阻滞剂美托洛尔比对照组更早地改善了下降的射血分数。该模型对了解Takotsubo心肌病的发病机制和β受体阻滞剂的疗效有价值。

Takotsubo cardiomyopathy is an increasingly recognized clinical syndrome characterized by acute reversible apical ventricular dysfunction. We tried to make a new model of Takotsubo-like cardiomyopathy in non-human primates. Echocardiography revealed that repeated intravenous infusion of epinephrine overdose in cynomolgus monkeys induced Takotsubo-like cardiomyopathy, which is characterized by progressive left ventricle and depressed systolic function with severe hypokinesis in apical regions and hyperkinesis in the basal region. Although this cardiac dysfunction almost normalized after a month even without any treatment, metoprolol, a β-blocker, improved the decreased ejection fraction earlier than the control. This model is valuable in understanding the pathogenesis of Takotsubo cardiomyopathy and effectivity of β-blockers.