Searching genes susceptible for life-style related diseases, such as diabetes and hypertension.

大多数寻找生活方式相关疾病易感基因的研究都没有考虑生活方式本身。该策略存在获得的结果在普通临床环境中没有用的风险。因此，我们通过详细的生活方式信息，如营养摄入和身体活动，寻找生活方式相关疾病的易感基因，并发现了几个生活方式相关疾病的易感基因。其中，发现两个基因（GNB3和FTO）分别与糖尿病（与盐摄入量有关）和肥胖（与体力活动有关）相关。这些发现似乎在普通临床环境中非常有用。

Most studies to find genes susceptible for life-style related diseases have been conducted without regard for life-style per se. This strategy conveys a risk that the results obtained were not useful in ordinary clinical settings. Therefore, we search genes susceptible for life-style related diseases with detailed information of life-styles such as nutritional intakes and physical activities, and found several genes susceptible for life-style related diseases. Of them, tow genes (GNB3 and FTO) were found as associated with diabetes in relation with salt intake and obesity in relation with physical activities, respectively. These findings seem to be very useful in ordinary clinical settings.