A case-control study of breast cancer in relation to the risk for estrogen levels in breast tissue and in situ estrogen production

我们利用62名绝经后乳腺癌患者的数据调查了血液和乳腺癌组织中激素水平与乳腺癌危险因素之间的关系。ER+或PR+乳腺癌患者组织中雌二醇（E2）水平是血液中雌二醇水平的43.7倍，ER-/PR-乳腺癌患者组织中雌二醇水平是血液中雌二醇水平的14.5倍。此外，在有母乳喂养史的乳腺癌患者中，受体阳性乳腺癌组织中E2水平趋于较高。E2可能是在乳腺组织中产生或从血液中提取的。母乳喂养史可能与乳腺组织中E2积聚的机制有关。

We investigated the associations between hormone levels in blood and in breast cancer tissue and risk factors of breast cancer using data from 62 postmenopausal breast cancer patients. Estradiol (E2) level in tissue was 43.7 times compared with that in blood among patients with ER+ or PR+ breast cancer, whereas 14.5 times among patients with ER-/PR-. In addition, E2 level in receptor positive breast cancer tissue tended to be higher among breast cancer patients with history of breast feeding. There is a possibility that E2 is produced in breast tissue or taken from blood. History of breast feeding may be related to the mechanisms responsible for the accumulation of E2 in breast tissue.