Study of molecular basis of motilin and growth hormone secretagogue receptors

胃动素、红霉素和Ghrelin是胃肠运动功能的重要内源性调节因子，由A-G蛋白偶联的胃动素受体和GHS受体介导。通过受体突变，我们在胃动素受体的跨膜区确定了红霉素结合和活性的新的关键残基。我们还建立了人胃动素受体转基因小鼠，并阐明了胃动素受体和GHS受体之间的关系。

Motilin, erythromycin and ghrelin are important endogenous regulators of gastrointestinal motor function, mediated by the class A G protein-coupled motilin receptor and GHS receptor. We have identified new critical residues in the transmembrane domains of the motilin receptor for erythromycin binding and activity using receptor mutagenesis. We have also generated human motilin receptor transgenic mice, and clarified relationship between motilin receptor and GHS receptor.