Searching for novel nutritional function of fish oil on infants using microarray database.

本研究旨在通过动物实验和基因芯片数据的荟萃分析，阐明二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）对婴儿生长发育的影响。母鼠仅在妊娠期和哺乳期喂养n-3脂肪酸缺乏饲料，幼鼠脑组织中DHA含量下降，但下降幅度小于其他组织。n-3脂肪酸缺乏状态的幼鼠肾脏n-6二十二碳五烯酸水平升高。因此，肾脏是研究长链脂肪酸生物学功能的重要靶组织。α-亚麻酸被证明不能改善婴儿n-3脂肪酸不足的状况。因此，婴儿需要鱼油中丰富的DHA。关于微阵列数据的荟萃分析研究，目前与n-3脂肪酸营养相关的现有数据不适合进行荟萃分析。由于所列数据预计会增加，因此需要进一步研究。

This research aimed to elucidate the effect of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on infant growth using animal experiment and meta-analysis of microarray data. Rats infant brain DHA level declined, when their mothers fed n-3 fatty acid deficient diet at only the gestation and lactation period, although the rate of decline of it was less than other tissues. Kidney n-6 docosapentaenoic acid level was increased in rat infant with n-3 fatty acids insufficient status. Therefore, kidney would be important target tissue for the study of long-chain fatty acid biological function. Alpha-linolenic acid was proved to be unable to improve insufficient n-3 fatty acids status in infant. Therefore, infants need DHA which is abundant in fish oil. About the investigation of meta-analysis of microarray data, the available data related to n-3 fatty acid nutrition were incompatible for meta-analysis at the present point. As listed data is expected to increase, further research would be needed.