Development of novel antibiotics that inhibit glutamate racemase as transition state analogues

多重耐药菌的出现和增加已成为一个更加严重的问题。在这方面，我指出，目的是谷氨酸消旋酶抑制，这是一个必要的酶的细菌，作为一个新的药物靶标。由于人类没有这种酶，可以预期这种酶的抑制剂没有副作用。根据底物的作用机理，设计并合成了底物类似物。实际上，有一种化合物对沙门氏菌表现出一定的抗菌活性。肺炎。

Emerging and increasing of multidrug resistant bacteria has become an even more serious issue. In this regard, I pointed the aim at glutamate racemase inhibition, which is an essential enzyme for bacteria, as a novel drug target. As human do not have this enzyme, one can expect that inhibitors of this enzyme do not have side effects. I designed and synthesized substrate analogues as potential inhibitors based on their action mechanism. Actually, one compound showed some antimicrobial activity on S. pneumoniae.