Rational molecular design and synthesis of near-infrared fluorescent probes for in vivo imaging of tumor hypoxia

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To visualize the hypoxic status of various tumor cells which are considered to be closely related to malignancy, I developed a probe that emit near-infrared fluorescence, which is suitable for non-invasive bioimaging, under hypoxia. First, to utilize hypoxia selective reductive metabolic reaction, I designed and synthesized probe molecules rationally in the aid of calculation based on density functional theory. Then, I evaluated them using culture cells by fluorescent microscopy. As a result, I invented a molecule that emit near-infrared fluorescence in tumor cells under hypoxic condition specifically.