Cross-talk of zinc transporter and Ca channels in cellular transport of cadmium

镉（Cd）是一种广泛分布于环境中的重金属，对包括人类在内的多种生物体造成不良影响。然而，细胞对镉的吸收和排泄机制还不清楚。据推测，细胞镉的吸收是介导的其他必需元素，如钙和锌的途径。本研究通过改变锌转运蛋白和钙通道的表达，研究了锌转运蛋白和钙通道在细胞镉转运（内流和外流）中的作用。

Cadmium(Cd) is a heavy metal widely distributed in the environment and causes adverse effects in a variety of organisms including humans. However, the mechanisms of cellular cadmium uptake and excretion have been poorly understood. It has been assumed that cellular Cd uptake is mediated by pathways for other essential elements such as Ca and Zn. The present study examined the involvement of Zn transporter and Ca channel in cellular Cd transport (influx and efflux) by using a cell line in which the expression of Zn transporter and Ca channel was changed.