Development of PEGylated thiol modified protein drugs for the treatment of sepsis

为了预防感染性休克和肝炎，通过静脉注射聚乙二醇偶联硫醇修饰的血清白蛋白(PEG-BSA-SH)，延长了还原型硫醇进入动物血液循环的时间。小鼠静脉注射后，聚乙二醇化牛血清白蛋白在血浆中的滞留时间延长。PEG-BSA-SH能有效抑制脓毒症小鼠和大鼠感染性休克和肝炎的发生。这些结果表明，聚乙二醇-牛血清白蛋白-SH是一种有前途的化合物，用于治疗感染性休克和肝炎。

To prevent septic shock and hepatitis, prolonged delivery of reduced thiols to the blood circulation was performed in animals by a bolus intravenous injection of polyethylene glycol (PEG)-conjugated thiols modified serum albumin (PEG-BSA-SH). PEG-BSA-SH exhibited a prolonged retention in the plasma after intravenous injection into mice. PEG-BSA-SH also effectively suppressed the septic shock and hepatitis in the sepsis mouse or rat model. These findings indicate that PEG-BSA-SH is a promising compound for the treatment of septic shock and hepatitis.