Regulatory role of AMP-kinase in the paraventricular hypothalamus in calorie intake and food preference.

下丘脑AMP激酶调节摄食行为对激素和营养信号的反应。在这里，我报告说，优先表达的组成型活性AMP激酶（CA-AMPK）的PVH双边使用慢病毒载体（神经元特异性突触蛋白1启动子）增加食物摄入量和体重下，实验室饮食。此外，CA-AMPK小鼠通过增强PVH中的脂肪酸氧化来增加对高碳水化合物饮食的偏好。相反，饮食诱导以及KKAy肥胖小鼠增加了对HFD的偏好，与矛盾的降低AMPK活性和FAO在PVH.Thus，我的研究结果表明，AMPK-FAO在PVH调节碳水化合物和脂肪饮食的偏好。此外，肥胖小鼠损害PVH中的AMPK-FAO系统，从而增加HFD摄入

Hypothalamic AMP-kinase regulates feeding behavior in response to hormonal and nutrient signals. Here I report that preferential expression of constitutively-active AMP-kinase (CA-AMPK) in the PVH blilaterally using lenti-virus vector (neuron specific-synapsin 1 promoter) increased food intake and body weight under lab chow diet. Furthermore, CA-AMPK mice increased the preference for high carbohydrate diet, by enhancing fatty acid oxidation in the PVH. In contrast, diet-induced as well as KKAy obese mice increased the preference for HFD, associated with paradoxically decreased AMPK activity and FAO in the PVH.Thus, my results suggest that AMPK-FAO in the PVH regulates the preference for carbohydrate and fat diets. Furthermore, obese mice impair the AMPK-FAO system in the PVH and thereby increase HFD intake