Analysis of rotavirus antigenemia in hepatopoietic stem cell transplanted children

我们已经报道了轮状病毒抗原血症已发现免疫功能正常的轮状病毒胃肠炎患者。然而，轮状病毒感染在免疫功能低下的移植受者的发病机制仍不清楚。采用酶联免疫吸附试验（ELISA）检测接受异基因造血干细胞移植（HSCT）患者血清中轮状病毒抗原水平。虽然抗原血症的持续时间明显长于免疫活性轮状病毒胃肠炎患者，但抗原水平并不高。

We've already reported that rotavirus antigenemia has been found in immunocompetent rotavirus gastroenteritis patients. However, the pathogenesis of rotavirus infection in immunocompromised transplant recipients remains unclear. Serially collected serum samples obtained from the patients receiving allogeneic hematopoietic stem cell transplants were measured rotavirus antigen levels using a previously established enzyme-linked immunosorbent assay.Rotavirus antigenemia occurred in hematopoietic stem cell transplant (HSCT) recipients. Although the duration of antigenemia was clearly longer than in immunocompetent rotavirus gastroenteritis patients, the levels of antigen were not as high.