The ^<17>O MRS/MRI for the tumor oxygen consumption rate in mice

利用~&lt；17&gt；O2气体代谢产生的~&lt；17&gt；O-水，用~&lt；17&gt；O MRS/MRI研究了荷瘤小鼠的肿瘤耗氧速率。分别在吸入富氧气体前后采集图像。将代谢产生的H2^&lt；17&gt；O的图像强度增量转化为H2^&lt；17&gt；O的生成量，这与文献中的生理数据吻合较好。我们证实这种方法有望成为监测肿瘤耗氧率的一种工具。

The tumor oxygen consumption rate in tumor-bearing mice using ^<17>O MRS/MRI was investigated based on the metabolically generated ^<17>O-water from ^<17>O2 gas. ^<17>O images were acquired before and after the inhalation of ^<17>O enriched oxygen gas. The increment in the ^<17>O image intensity due to the metabolically generated H2^<17>O from ^<17>O2 was converted to the quantity of produced H2^<17>O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.