Novel hybrid bone filling material of self-assembling peptide scaffold and artificial framework

骨填充材料应具有足够的承重强度和足够的骨传导性能。但这些特性是不兼容的。在本研究中，我们使用了自组装多肽PuraMatrix和聚醚醚酮笼子的杂化材料。PuraMatrix具有良好的骨传导性能，聚醚醚酮Cage具有足够的强度作为骨填充材料。结果表明，这些杂化材料可用于修复大鼠股骨的骨缺损。

Bone filling materials should have enough strength for weight bearing and adequate osteoconductive property. But these properties are incompatible. In this study, we used hybrid materials of Self-assembling Peptide PuraMatrix and Polyetheretherketone Cage. PuraMatrix has good osteoconductive property and Polyetheretherketone Cage has enough strength for bone filing material. We showed that these hybrid materials were useful for repairing the bone defects in Rat's femurs.