Mechanism of the development of central pain - relationships with intracerebral adrenoceptors

为了阐明导致中枢性疼痛发生的因素，我们在动物身上研究了局麻药和脑内肾上腺素受体的作用之间的关系。心得安是一种β肾上腺素能受体拮抗剂，小剂量抑制局部麻醉剂对中枢神经系统的作用，而不影响呼吸、循环条件或疼痛阈值。与静脉给药相比，脑室内心得安抑制局麻药作用的潜力约为100倍。提示局麻药的中枢神经系统作用受脑内肾上腺素受体的影响，这些受体可能通过gaba能神经元影响痛阈。

For elucidating the factors contributing to the development of central pain, relationships between the effect of local anesthetics and intracerebral adrenoceptors were examined in animals. Propranolol, a beta adrenoceptor antagonist, suppressed the effect of local anesthetics on the central nervous system at small doses which do not affect the respiratory, circulatory conditions or threshold for pain. Intracerebroventricular propranolol was approximately 100-times more potential for suppressing the effect of local anesthetics compared with that administered intravenously. These results suggest that central nervous system effect of local anesthetics was affected by intracerebral adrenoceptors and these receptors may affect pain threshold via GABAergic neurons.