Development of Titanium Implant materials with high corrosion resistance and osteoconductivity

我们检测到含0.5%铂的钛和钛合金的机械强度和耐腐蚀性的改善。我们可以对钛及钛合金进行表面改性。研究了骨髓间充质干细胞在这些材料上的成骨、增殖和分化能力。这表明钙改性的材料在各方面都优于未改性的材料。为研究钛与骨的结合情况，将钛材料植入大鼠胫骨，测量骨的结合率。结果表明，经钙改性的材料比未改性的材料能更好地提高骨与材料的接触率和骨与材料的连接速度。这表明，我们可以使用短而薄的种植体在严重的地方，骨量少。增加骨连接到种植体的速度使得种植体治疗的时间足够短。

We detected the improvement of mechanical strength and corrosion resistance of titanium and titanium alloys containing 0.5% platinum. We could modify surface of titanium and titanium alloys. We investigated cell-adhesiveness, cell-proliferation and cell differentiation ability on these materials with bone mallow stem cell. This shows that the materials modified by calcium is better than those not modified in all ways. To investigate the connection of titanium with bone, we placed the materials in tibia of rats, and measured the contact ratio of bone. The result shows that the contact ratio of the bone and the speed of connection of bone with the materials were improved in those modified by calcium better than those not modified. It indicate the possibility that we can use short and thin implants on the severe site where the amount of bone is small. Increasing the velocity of bone connection to implants make the period of implant treatment sufficiently short.