Investigation of disease-associated proteome maps in oral lesion

本研究利用蛋白质组学的方法对口腔病变组织中的蛋白质组进行了初步的研究。利用这种策略，我们检测了恶性纤维组织细胞瘤（MFH）中的四个上调蛋白和四个下调蛋白。我们采用我们以前的微阵列数据，包括口腔鳞状细胞癌和腺样囊性癌，比较MFH的蛋白表达模式。然后，我们通过比较微阵列数据中的mRNA表达模式与蛋白质组学数据中的蛋白质表达模式，选择了三种蛋白质，Transgelin 2，磷酸甘油酸激酶1和波形蛋白。因此，我们的数据表明，这三个蛋白可能是一个潜在的新的分子标记，不仅口腔MFH，而且口腔恶性肿瘤。

In this study, we performed proteomics approach to identify the disease-associated proteome maps in oral lesion. Using this strategy, we detected four up-regulated proteins and four down-regulated proteins in malignant fibrous histiocytoma (MFH). We adopted our previous microarray data, including oral squamous cell carcinoma and adenoid cystic carcinoma, to compare with patterns of protein expressions in MFH. Then, we selected the three proteins, Transgelin 2, phosphoglycerate kinase 1 and Vimentin, by comparing patterns of mRNA expressions in microarray data with patterns of protein expressions in proteomics data. Therefore, our data indicate that three proteins may be a potential novel molecular marker of not only oral MFH but also oral malignant tumors.