The possibility of osteoproteger in as a topical application drug inperiodontal therapy.

本研究旨在探讨骨保护素（OPG）对实验性牙周炎大鼠牙槽骨吸收的影响。形态学分析显示，OPG通过减少破骨细胞数量显著抑制牙槽骨吸收。opg处理组与未处理组IL-1β纤维表达相似。OPG治疗对上皮下结缔组织中多形核白细胞和血管的数量没有影响。这些结果表明，OPG可能是一种有用的外用药物在牙周治疗。

The purpose of this study was to investigate the effects of osteoprotegerin (OPG), decoy reseptor of RANKL, on alveolar bone resorption in rat experimental periodontitis. Morphological analysis revealed that alveolar bone resorption was significantly inhibited by OPG treatment through a decrease of osteoclast number. The expression of IL-1β fiwas similar between OPG-treated and non-treated groups. The numbers of polymorphonuclear leukocyte and blood vessel in the subepithelial connective tissue were not affected by OPG treatment. These results show that OPG may be useful as a topical application drug in periodontal therapy.