Study of molecular mechanism in muscle atrophy and fiber type change by using bioimaging.

骨骼肌随着年龄的变化不仅出现肌纤维萎缩，而且纤维类型由快型向慢型转变，但其机制尚不明确。在本研究中，我们进行了转基因小鼠的培养，通过荧光蛋白的表达可以明确区分快型纤维和慢型纤维。未来，通过研究这些小鼠的纤维类型与年龄相关的变化机制，将有助于发现肌肉萎缩相关现象和生物标志物的新发现。

Not only atrophy of muscle fibers but also fiber type transition from fast-type to slow-type has been observed as age-related changes of skeletal muscle, however, these mechanism remain to be elucidated. In this study, generation of genetically modified mice, which could definitely distinguish between fast-type fiber and slow-type fiber by expressions of fluorescence proteins, was performed. In future, it will enable novel findings about muscular atrophy-related phenomena and biomarkers by investigating the mechanism of age-related change in fiber type using these mice.