Research of the role of tenascin C in coronary development

为心脏提供氧气和营养的冠状血管细胞被认为起源于心外膜前。我们检测了细胞外糖蛋白tenascin C在冠状动脉干细胞形成和心外膜前源性细胞上皮间充质转化中的作用。tenascin C在发育中的冠状动脉茎和冠状动脉平滑肌细胞中表达。提示tenascin C促进心外膜原源性细胞向肌成纤维细胞/平滑肌细胞的分化，但不诱导细胞在体外系统的侵袭/迁移。

Cells destined to form the coronary vasculature which supply oxygen and nutrients to the heart are thought to originate in the proepicardium. We examined an extracellular glycoprotein tenascin C in formation of the coronary stem and epithelial mesenchymal transformation of proepicardium-derived cells. Expression of tenascin C was seen in developing coronary stems and coronary smooth muscle cells. It is suggested that tenascin C facilitates the differentiation of proepicardium-derived cells into myofibroblast/smooth muscle cells, however, not induce the invasion/migration of the cells in vitro system.