Regenerative medical therapy using bone marrow derived cells

最近的研究表明，骨髓细胞转分化为各种细胞谱系，包括皮肤。对再生医学的投资已被用于各自的模型小鼠作为临床前步骤。为了彻底治愈目前尚无有效治疗方法的大疱性表皮病，本研究进行了基础研究。首先，作为基础研究的一步，证明了存在从骨髓来源的细胞向角质形成细胞诱导转分化的角质形成细胞分泌的因子。接下来，作为临床前步骤，将正常小鼠的骨髓移植到大疱性表皮病模型小鼠之一的XVII型胶原基因敲除小鼠中，诱导缺陷蛋白（XVII型胶原）的产生并改善小鼠的临床表现。提示正常小鼠骨髓移植治疗大疱性表皮病是有效的治疗方法之一。

Recent studies have suggested that bone marrow cells transdifferentiate to a variety of cellular lineages including skin. Investments for regenerative medicine have been used respective model mouse as a preclinical step. In our study, we conducted basic research to achieve radical cure for epidermolysis bullosa to which there is no effective therapy.First as a basic research step, we demonstrated the existence of the factors secreted from keratinocytes that induces transdifferentiation from bone marrow derived cells into keratinocyte. Next as a preclinical step, bone marrow transplantation from normal mouse to type XVII collagen knock out mouse, one of the epidermolysis bullosa model mouse, induced production of the defect protein (XVII type collagen) and improvement of clinical manifestation of the mouse. So we suggested that the bone marrow transplantation from normal mouse to model mouse can be one of the effective therapies for epidermolysis bullosa..