The role of the bias in Th-subset 1/2/17 on pathogenesis of atopic dermatitis.

最近的一项研究表明，两种受损伤的皮肤屏障功能和过敏免疫特性都是atopic皮肤炎和接触皮肤炎的重要方面。However，Th17细胞在接触皮肤病的病理学中的作用还不清楚。在这项研究中，我们调查了第17个细胞在过敏性接触皮肤病中的作用。“红细胞干细胞被认为是一种稳定地过度膨胀的ROR，而不是被移植到放射性老鼠和人工过敏性皮肤病被诱导到老鼠身上。”移植老鼠中的皮肤病与控制老鼠相比是令人沮丧的。这些发现表明ROR的稳定性过度表达的结果在Th17个细胞的增加中，但在Treg细胞的增加中抑制了过敏作用。

Recent studies demonstrated that both impaired skin barrier function and allergic immunonogical property are important aspects of the pathogenesis of atopic dermatitis and contact dermatitis. However, the role of Th17 cells in the pathogenesis of contact dermatitis is not clear. In this study, we investigated the role of Th17 cells in allergic contact dermatitis. The hematopoietic stem cells which constitutively overexpress ROR・t were transplanted to irradiated mice and artificial allergic dermatitis was induced to the mice. The dermatitis in the transplanted mice was suppressed compared to the control mice. These findings indicate that constitutive overexpression of ROR ・t results in the increase of Th17 cells, but suppressed allergy due to the increase of Treg cells.