The course of cognitive functioning of first episode schizophrenia and effects of cognitive rehabilitation

对首发精神分裂症患者进行前瞻性和横断面随访，以明确认知功能对精神症状和社会功能的影响。12名被诊断患有DSM IV的精神分裂症患者在基线、6个月后和1年后使用BACS-J、PANSS、LSP和GAF进行评估。1年后，言语记忆、运动速度和执行功能显著改善。1年后，社会关系、沟通技巧和GAF也有显著改善。19例首发精神分裂症（随访6个月后）与18例推测发病时间为5年前的精神分裂症（DSM-IV）进行比较。5年组在语言流畅性、社会关系、一般病理方面明显优于首发组。五岁组在言语记忆和执行功能上明显变差。

Cognitive impairment of first episode schizophrenia was followed prospectively and cross-sectional to clarify time course and influence of cognitive functioning on psychiatric symptoms and social functioning. Twelve schizophrenia diagnosed with DSM IV were evaluated at baseline, after 6 months, and after 1 year using with BACS-J, PANSS, LSP, and GAF. Verbal memory, motor speed, and executive functioning were significantly improved after 1 year. Social relationship, communication skills, and GAF also significantly improved after 1 year. Nineteen first episode schizophrenia (after 6 month follow up point) were compared with 18 schizophrenia (DSM-IV) who were speculated that onset was 5 years ago. Five years group were significantly better in verbal fluency, social relationship, and general pathology than first episode group. Five years group were significantly worse in verbal memory and executive functioning.