Serial alteration of cerebral blood flow and glucose metabolism before and after the non-smoking therapy in young men with smoking habit

慢性吸烟与局部脑血流量(RCBF)下降有关，本研究旨在探讨年轻健康男性戒烟前后rCBF和脑葡萄糖代谢的动态变化。招募了10名有吸烟习惯的年轻男性吸烟者(年龄21-26岁，平均年龄21.5岁)。所有受试者都没有任何神经系统疾病的病史。观察非吸烟治疗前后局部脑血流量和糖代谢的动态变化。~(99)m&gt；~(99m)Tc-SPECT用于评价rCBF分布，~(18)&gt；F-FDG PET用于评价基线(吸烟期)和戒烟后的脑葡萄糖代谢。非吸烟治疗后，左侧额叶、左侧颞叶、中央沟周围、豆状核和右侧丘脑rCBF较基线状态显著增加。同样，在非吸烟治疗后，左侧中回和左侧中下回的FDG摄取显著增加。总而言之，非吸烟治疗增加了有吸烟习惯的年轻男性的rCBF和葡萄糖摄取。

Chronic cigarette smoking is known to be associated with decrease of regional cerebral blood flow (rCBF).The aim of this study was to evaluate the serial alteration of rCBF and cerebral glucose metabolism pre and post cessation of smoking therapy in younger healthy men. Ten young male smokers (aged 21-26 years, mean age 21.5 years) with a smoking habit were recruited. None of the subjects had a history of any neurological disorder. We evaluated the serial change of regional cerebral blood flow and glucose metabolism before and after non-smoking therapy. ^<99m>Tc-SPECT was used to evaluate rCBF distribution and ^<18>F-FDG PET was used to evaluate cerebral glucose metabolisms in both at baseline (during smoking) and after they had quit smoking. After non- smoking therapy, rCBF significantly increased compared with those at baseline condition in left frontal lobe, left temporal lobe, around central sulcus, lenticular nuclei and right thalamus. Similarly, FDG uptake increased significantly, in the left middle temporal gyrus and the left middle inferior gyrus after non-smoking therapy. In conclusion, non-smoking therapy increased rCBF and glucose uptake in young men with smoking habit.