Effects of bFGF-incorporated gelatin hydrogel and bone marrow-derived Schwann cell transplantation after spinal cord contusion injury in rats

在大鼠脊髓挫伤模型上，将含bFGF（20μg）的明胶水凝胶（gelatin hydrogel，GH）注射于损伤中心，观察bFGF缓释系统对脊髓挫伤的治疗作用。通过BBB测试在9周内评估运动恢复。在第5、7和9周时，对所有大鼠后爪的感觉异常进行了评价，虽然bFGF-GH和GH组的BBB评分优于盐水组，但差异未达到统计学显著性。第七周时，bFGF-GH组的感觉异常明显少于生理盐水组。我们的研究结果表明，掺入bFGF-GH的明胶水凝胶可能具有缓解脊髓损伤后机械性异常性疼痛的治疗潜力。

We investigated the effects of a sustained-release system of bFGF from gelatin hydrogel in a rat spinal cord contusion model.One week after spinal cord contusion, gelatin hydrogel (GH) containing bFGF (20μg) was injected into the lesion epicenter of rats. Locomotor recovery was assessed over nine weeks by BBB testing. Sensory abnormalities in the hind paws of all the rats were evaluated at five, seven, and nine weeks.Although BBB scores were better in the bFGF-GH and GH groups than in the saline group, the differences did not reach statistical significance. The bFGF-GH group showed significantly less sensory abnormalities than the saline group at seven weeks.Our study findings suggest that bFGF-incorporated gelatin hydrogel could have therapeutic potential for alleviating mechanical allodynia following spinal cord injury.