Niche of treatment of adiposed drived stem cell for renal damage by low serum culture

急性肾损伤(AKI)是一个高死亡率和有限的因果治疗的主要临床问题。细胞治疗已被认为是改善AKI病程和预后的一种潜在手段。我们观察了低血清培养的脂肪组织来源的干细胞和再生细胞(ADRC)对AKI大鼠缺血再灌注(I-R)模型的可能肾保护作用。结果表明，ADRC组大鼠的血肌酐和BUN较对照组显著降低。用药时，ADRCs组肾小管周围血流量高于对照组。总而言之，这些结果提示ADRC疗法在AKI患者中具有潜在的临床作用。

Acute kidney injury (AKI) represents a major clinical problem with high mortality and limited causal treatments. The use of cell therapy has been sug- gested as a potential modality to improve the course and outcome of AKI.We investigated the possible renoprotection of low serum cultured adipose tissue-derived stem and regenerative cells (ADRCs) in a rat ischemia-reperfusion (I-R) model of AKI. We demonstrated that ADRC group drastically significantly reduced than control group serum creatinine and BUN. In adition, ADRCs group increased than control group in peritubular blood flow. Collectively, these results suggest a potential clinical role for ADRC therapy in patients with AKI.