New Model of BPH with Slowly Advancing Obstruction to Investigate Pathophysiology and Mechanism of Obstructed Bladder

本研究以beagle犬为研究对象，建立了一种新的良性前列腺阻塞动物模型，该模型随着前列腺的生长，前列腺阻塞膀胱出口。该模型显示尿频，排尿时逼尿肌压力增加，残余量轻微，与良性前列腺增生（BPH）患者的排尿行为相似。在新模型梗阻膀胱中，平滑肌生长因子（HB-EGF）的表达高于TGF-β1等纤维生长因子的表达，平滑肌细胞凋亡受到抑制。这些结果提示代偿性肌肉肥大或增生可能有助于维持逼尿肌的收缩能力。

In the present study, using beagle dogs, we created a new animal model of benign prostatic obstruction, in which prostate would occlude the bladder outlet as prostate grows. This model showed urinary frequency, an increase in detrusor pressure during voiding and a mild degree of residual volume, which resembles a micturition behavior of patients with benign prostatic hyperplasia (BPH). In the obstructed bladder of this new model, the expression of smooth muscle growth factor (HB-EGF) was higher than that of fibrous growth factor such as TGF-β1while smooth muscle cell apoptosis was suppressed. These results suggest that compensatory muscle hypertrophy or hyperplasia may serve to sustain the ability of detrusor to contract.