Research for establishment of prevention for urolithiasis by considering metabolic syndrome

尿石症在发生机制上类似于代谢综合征。然后，我们从遗传和环境因素考虑代谢综合征，进行了建立预防尿石症的研究。在遗传学研究中，我们分析了OPN基因的SNPs，并将其结果与患者的背景和结石成分进行了比较。我们发现特异性SNPs是结石复发的风险标记。在环境研究中，我们发现NFκB作为一种应激感受性信号，在氧化应激条件下增加，线粒体受到损伤。

Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.