Clinical usefulness and application of Taxol-resisitance molecules

We found that head and neck cancer stem cells appeared to be resistant to the treatment of anti-cancer drugs。We did not find any differences of TRAG-3mRNA expressions between CD44+and CD44-cells of head and neck cancer cell lines。In addition，CD44+cells significantly suppressed T cell proliferation。As for cytokine production，IFN·was reduced，however，IL-10was increased when co-cultured with CD44+cells.Thus，immunosuppressive mechanisims other than TRAG-3expression may have a role for anti-cancer drug resistance。

We found that head and neck cancer stem cells appeared to be resistant to the treatment of anti-cancer drugs. We did not find any differences of TRAG-3 mRNA expressions between CD44+ and CD44- cells of head and neck cancer cell lines. In addition, CD44+ cells significantly suppressed T cell proliferation. As for cytokine production, IFN・was reduced, however, IL-10 was increased when co-cultured with CD44+ cells. Thus, immunosuppressive mechanisims other than TRAG-3 expression may have a role for anti-cancer drug resistance.