Studies on the pathogenesis and development of pharmacological treatment of retinopathy of prematurity

采用实时荧光定量PCR技术研究氧致视网膜病变小鼠和对照组的基因表达谱。与炎症相关的基因在新生血管（NV）发生前2天出现上调，并持续到NV消失后数天。另一方面，血管内皮生长因子和血管生成素-2等与NV相关的基因在NV发生前1天至NV消失时出现上调。

Gene expression profiles of oxygen-induced retinopathy and control mice were investigated using real-time PCR. Upregulation of genes associated with inflammation were observed 2 days before the development of neovascularization (NV), and continued until a few days after disappearance of NV. On the other hand, upregulation of genes associated with NV, such as vascular endothelial growth factor and angiopoietin-2, were observed from one day before the development of NV until the disappearance of NV.