Generation of nitric oxide synthase transgenic mice and analysis of their visual function

我们产生了5系诱导型一氧化氮合酶转基因小鼠。眼底检查发现3个转基因小鼠系的视网膜玻璃疣。这些结果表明，视网膜外层中过表达的一氧化氮引起小鼠视网膜中的氧化应激和退行性变化，如在年龄相关性黄斑变性患者中所见。

We generated 5 lines of inducible nitric oxide synthase transgenic mice. Fundus examination revealed retinal drusen in 3 lines of transgenic mice. These results indicated that nitric oxide overexpressed in the outer layer of retinas caused oxidative stress and degenerative change in mouse retinas as is seen in the patients of age-related macular degeneration.