The pathogenic mechanisms of peripheral nerve disorders associated with severe sepsis -A study of the protective effect of X factor inhibitor-

虽然周围神经疾病与脓毒症有关，但涉及的致病机制尚未阐明，治疗也没有很好地建立。我们的数据表明，没有电镜变性的基强度增加意味着阈值的改变，而不是退行性变化，可能在脓毒症的早期阶段在周围神经组织中发展。这表明这些因素可能与周围神经疾病如危重病多发性神经病有关。此外，由于达那肝素和抗凝血酶3的联合作用导致临床改善，我们的数据表明，它可能会显着影响与败血症相关的严重周围神经病变的药物治疗。

Although peripheral nerve disorders are associated with sepsis, the pathogenic mechanisms involved have yet to be clarified and treatment is not well established. Our data demonstrated that increase of rheobase without electro-microscopic degeneration implied that alteration of threshold, rather than degenerative changes, might develop in peripheral nerve tissue in the early phases of sepsis. This suggests the possibility that these factors are likely to be associated with peripheral nerve disorders such as critical illness polyneuropathy. Furthermore, since the combined effect of danaparoid and antithrombin3 resulted in clinical improvement, our data suggests that it might significantly affect the medical treatment of severe peripheral neuropathy associated with sepsis.