Evaluation of the neurological substrates for stress induced oral dysesthesia.

杏仁核中央核和蓝斑核被证明向三叉神经中脑核发送直接的投射。注射神经元束示踪剂（生物素化右旋糖酐胺，Fast blue）显示，向中脑三叉神经核注射有限的Fast blue可导致中央杏仁核逆行标记细胞。中央杏仁核的正位标记导致三叉神经中脑核终末肿胀。电镜观察证实了这些发现。利用生物素化右旋糖酐胺对蓝斑座进行选择性细胞标记，发现蓝斑座神经元的轴突直接与三叉神经节中脑核细胞相连。结果表明，情绪和应激直接改变了牙周韧带和咀嚼肌的本体感受信号。

The central nucleus of amygdala and the locus coeruleus are proved to send direct projections to the mesencephalic trigeminal nucleus. Injections of neuronal tract tracers (biotinylated dextran amine, Fast blue) revealed that limited injections of Fast blue into the mesencephalic trigeminal nucleus resulted in retrogradely labeled cells in the central amygdaloid nucleus. Orthograde labeling of the central amygdaloid nucleus resulted in terminal swellings in the mesencephalic trigeminal nucleus. Electron microscopic observation confirmed these findings. Selective cellular labeling of the locus coeruleus using biotinilated dextran amine revealed that the axons of locus coeruleus neurons were followed directly to the mesencephalic trigeminal nucleus gangion cells. The results suggest that emotion and stress directly modify proprioceptive signals from periodontal ligament and masticatory muscles.