Oral cancer therapy by differential temperature control using nano-particle

与37℃和42℃处理相比，44℃处理明显抑制了细胞的增殖。42℃和44℃热处理后12h细胞死亡率分别为5.0%和17.4%。计算基因网络分析证明了三个重要的基因网络。对于42℃热处理，显著基因网络包含HSP70、DNAJB1等多个HSPs。在44℃时，以CDK6和JUN为核心的重要基因网络分别与细胞周期和细胞死亡相关。这些发现将为热疗在口腔癌治疗应用中的生物分子机制提供新的见解。

The cell proliferation was significantly suppressed by 44℃ treatment compared with 37℃ and 42℃. The cell death ratios at 12 hours after heat treatment were 5.0% at 42℃ and 17.4% at 44℃. Computational gene network analysis demonstrated the threesignificant gene networks. As for heat treatment at 42℃, the significant gene network contained many HSPs such as HSP70 and DNAJB1. As for at 44℃, the significant gene networks whose core contained CDK6 and JUN were associated with cell cycle and cell death, respectively. These findings will provide novel insight into the biomolecular mechanisms of hyperthermia in therapeutic application for oral cancer therapy.