Identification of characteristic salivary proteins from disease mouse and application on diagnosis of xerostomia

我们确定了在非肥胖糖尿病（NOD）小鼠腮腺中显示特征性表达的蛋白质，该小鼠显示自身免疫性糖尿病并用作干燥综合征的模型。通过cDNA微阵列分析，选择几丁质酶作为特征性分泌蛋白。几丁质酶在腮腺中表达，并分泌到唾液中。糖尿病发病后，腮腺几丁质酶表达增加，唾液中几丁质酶浓度升高。

We determined the proteins showing characteristic expression in parotid glands from non-obese diabetic (NOD) mouse which shows autoimmune diabetes and is used as a model for Sjogren syndrome. Chitinase was selected by cDNA microarray analysis as a characteristic secretory protein. Chitinase was expressed in the parotid glands and secreted in saliva. After diabetes onset, the expression of chitinase was increased in the parotid glands and the concentration of chitinase in saliva was increased.