Clarification of the mechanisms to control odor-evoked responses using genetically manipulated mice with neuronal modifications.

在这项研究中，我们发现，特定的神经回路在主嗅觉系统，从不同的区域上的背域的嗅球调节各种社会交流反应，除了恐惧反应。本研究建立了嗅觉系统特异性神经回路部分缺失的遗传操作小鼠模型，并建立了气味诱发特异性行为和情绪的定量分析系统。根据这些结果，我们建立了基于主嗅球特定神经回路功能的研究气味诱发反应神经机制的方法。

In this study, we found that specific neuronal circuits in the main olfactory system which start from distinct area on the dorsal-domain of the olfactory bulb regulate various social communication responses in addition to fear responses. Various kinds of genetically manipulated mice with partial depletions of the specific neuronal circuits in the main olfactory system were generated, and quantitative analysis systems for odor-evoked specific behaviors and emotions were constructed. From these results, we established the methods to study the neuronal mechanisms to regulate odor-evoked responses based on the functions of the specific neuronal circuits in the main olfactory bulb.