Development of a novel anticancer drug targeting UBL-UBA family protein

本研究的目的是开发一种针对UBL-UBA家族蛋白的抗癌药物。我发现，抑制增殖的化合物Gut-70与泛素1结合。Gut-70积累了细胞间泛素化的蛋白质，蛋白质组分析表明，Gut-70与蛋白酶体抑制物属于同一簇。这些结果表明，Gut-70以泛素1为靶点，从而抑制泛素-蛋白酶体系统，从而抑制癌细胞的生长。

The purpose of this study is to develop an anticancer agent targeting UBL-UBA family protein. I found that GUT-70, an antiproliferative compound, binds to ubiquilin 1. GUT-70 accumulated intercellular ubiquitinated proteins, and proteome analysis showed that GUT-70 is classified into the same cluster as a proteasome inhibitor. These results suggest that GUT-70 targets ubiquilin 1, thereby suppressing ubiqutin-proteasome system, resulting in the growth inhibition of cancer cells.